No association of genetic variants of liver X receptor-beta with Alzheimer's disease risk
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Am J Med Genet B Neuropsychiatr Genet. 2007 Dec 14 [Epub ahead of print]
Rodriguez-Rodriguez E, Llorca J, Mateo I, Infante J, Sanchez-Quintana C, Garcia-Gorostiaga I, Fernandez-Viadero C, Pena N, Berciano J, Combarros O.
Neurology Service and Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), "Marques de Valdecilla" University Hospital (University of Cantabria), Santander, Spain.
Apolipoprotein E (APOE) epsilon4 allele is the strongest hitherto known risk factor for sporadic Alzheimer's disease (AD). Liver X receptor-beta (LXRbeta) is a transcription factor that controls expression of genes involved in brain cholesterol metabolism, and one of the main LXRbeta targets is APOE. To evaluate the relationship between LXRbeta genetic variants and AD, independently or in concert with the APOE epsilon4 allele, we examined three LXRbeta polymorphisms located in introns 2 (rs 2695121), 5 (rs 1052533), and 7 (rs 1405655), in 414 Spanish AD patients and 447 controls. The current study does not demonstrate an association between LXRbeta genotypes or haplotypes and AD, neither in the total sample nor when the populations were stratified for the presence or absence of the APOE epsilon4 allele.
PubMed ID and Record
Am J Med Genet B Neuropsychiatr Genet. 2007 Dec 14 [Epub ahead of print]
Rodriguez-Rodriguez E, Llorca J, Mateo I, Infante J, Sanchez-Quintana C, Garcia-Gorostiaga I, Fernandez-Viadero C, Pena N, Berciano J, Combarros O.
Neurology Service and Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), "Marques de Valdecilla" University Hospital (University of Cantabria), Santander, Spain.
Apolipoprotein E (APOE) epsilon4 allele is the strongest hitherto known risk factor for sporadic Alzheimer's disease (AD). Liver X receptor-beta (LXRbeta) is a transcription factor that controls expression of genes involved in brain cholesterol metabolism, and one of the main LXRbeta targets is APOE. To evaluate the relationship between LXRbeta genetic variants and AD, independently or in concert with the APOE epsilon4 allele, we examined three LXRbeta polymorphisms located in introns 2 (rs 2695121), 5 (rs 1052533), and 7 (rs 1405655), in 414 Spanish AD patients and 447 controls. The current study does not demonstrate an association between LXRbeta genotypes or haplotypes and AD, neither in the total sample nor when the populations were stratified for the presence or absence of the APOE epsilon4 allele.
PubMed ID and Record
posted by Dr.Koudinov @ 11:18 AM
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