Altered performance of reelin-receptor ApoER2 deficient mice on spatial tasks using the Barnes maze

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Behav Neurosci. 2007 Oct;121(5):1101-5.
Barr AM, MacLaurin SA, Semenova S, Fish KN, Markou A.
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

The apolipoprotein E receptor 2 (ApoER2), expressed predominantly in forebrain
regions including the hippocampus, is 1 of 2 receptors for the extracellular
matrix protein reelin, which is critical for cortical development. Previous
studies of ApoER2 mutant mice have indicated deficits in synaptic plasticity and
learning. The current authors assessed learning and memory of ApoER2 knockout
and wild-type mice on the Barnes circular maze. Mice were trained in this task
for 22 days, followed by memory recall and reversal tests. ApoER2 knockout mice
were initially slower to complete the task, but by Day 22 they were more
accurate than wild-type mice on several indices. There were no differences in
memory assessed by the recall task, but ApoER2 knockout mice performed
significantly worse on the memory reversal task. ApoER2 knockout mice also
displayed altered use of specific search strategies and relationship of these
strategies to errors made on the maze. (PsycINFO Database Record (c) 2007 APA,
all rights reserved).

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