Serum lipids and hippocampal volume: The link to Alzheimer's disease?
Citation: Wolf H, Hensel A, Arendt T, Kivipelto M, Winblad B, Gertz HJ. Serum lipids and hippocampal volume: The link to Alzheimer's disease? Ann Neurol. 56(5), 745-749 (25 Oct 2004) . doi: 10.1002/ana.20289.
Abstract: The association between hippocampal volume (as a presumed index of Alzheimer's disease pathology) with serum total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol was studied in 86 elderly subjects with a range of cognitive functions. High-density lipoprotein cholesterol, but not low-density lipoprotein cholesterol or total cholesterol, was associated with hippocampal volume and dementia. This is compatible with protective effects of high-density lipoprotein cholesterol on hippocampal atrophy and Alzheimer's disease.
Authors: Henrike Wolf, MD, PhD; Anke Hensel, DP; Thomas Arendt, MD, PhD; Miia Kivipelto, MD, PhD; Bengt Winblad, MD, PhD; Hermann-Josef Gertz, MD, PhD
Authors Institution: Department of Neurotec, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden, e.mail: henrike.wolf[at]neurotec.ki.se ; Department of Psychiatry, University of Leipzig, Leipzig, Germany; Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany
First author key note: "Disturbances in brain cholesterol metabolism have been associated with all principal pathological features of Alzheimer's disease (AD). Although serum and brain cholesterol are classically believed to be independent, some studies suggested a link between serum cholesterol and AD-like pathology or risk of dementia. In light of these findings, we studied the association between hippocampal volume – as a presumed index of AD pathologyv- and serum cholesterol in 86 elderly subjects with a range of cognitive functions. Serum HDL-cholesterol, but not LDL- or total cholesterol, was associated with hippocampal volume and dementia. This is compatible with protective effects of HDL-cholesterol on hippocampal atrophy and Alzheimer's disease. The finding could reflect the role of cholesterol and lipoproteins in facilitating synaptic plasticity in the aging human brain."
Further reading: see related articles at Neurobiology of Lipids.
Abstract: The association between hippocampal volume (as a presumed index of Alzheimer's disease pathology) with serum total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol was studied in 86 elderly subjects with a range of cognitive functions. High-density lipoprotein cholesterol, but not low-density lipoprotein cholesterol or total cholesterol, was associated with hippocampal volume and dementia. This is compatible with protective effects of high-density lipoprotein cholesterol on hippocampal atrophy and Alzheimer's disease.
Authors: Henrike Wolf, MD, PhD; Anke Hensel, DP; Thomas Arendt, MD, PhD; Miia Kivipelto, MD, PhD; Bengt Winblad, MD, PhD; Hermann-Josef Gertz, MD, PhD
Authors Institution: Department of Neurotec, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden, e.mail: henrike.wolf[at]neurotec.ki.se ; Department of Psychiatry, University of Leipzig, Leipzig, Germany; Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany
First author key note: "Disturbances in brain cholesterol metabolism have been associated with all principal pathological features of Alzheimer's disease (AD). Although serum and brain cholesterol are classically believed to be independent, some studies suggested a link between serum cholesterol and AD-like pathology or risk of dementia. In light of these findings, we studied the association between hippocampal volume – as a presumed index of AD pathologyv- and serum cholesterol in 86 elderly subjects with a range of cognitive functions. Serum HDL-cholesterol, but not LDL- or total cholesterol, was associated with hippocampal volume and dementia. This is compatible with protective effects of HDL-cholesterol on hippocampal atrophy and Alzheimer's disease. The finding could reflect the role of cholesterol and lipoproteins in facilitating synaptic plasticity in the aging human brain."
Further reading: see related articles at Neurobiology of Lipids.
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