A link between cholesterol, CNS, synapse and brain diseases: is there a need for a reinvention?
Citation: Koudinov AR. A link between cholesterol, CNS, synapse and brain diseases: is there a need for a reinvention? Neurobiol Lipids Vol. 2, 1 (2 April 2003). Available at: http://neurobiologyoflipids.org/content/2/1/
Abstract: Since 1987 we know that "apolipoprotein E-containing lipoproteins may function to redistribute lipid and regulate cholesterol homeostasis within the brain". In 1993 we learned about the importance of "cholesterol synthesis and lipoprotein reuptake during synaptic remodeling". Over the past decade this knowledge was amassed (thanks to the pivotal contribution by many scientists) and elucidated the role for the failure of cholesterol homeostasis proper in neuronal degeneration. Still many questions remain. However, the statement that "a breakdown of cholesterol homeostasis may also play a role in neurodegenerative processes that have not been associated with this lipid so far" seems outdated.
Authors:Alexei R. Koudinov
Authors Institution: Russian Academy Med Sci, Moscow, Russian Federation, c/o P.O.Box 1665, Rehovot 76100 Israel, email: alexei[at]koudinov.info
Key words: cholesterol homeostasis; neurodegeneration; lipoprotein; apolipoprotein; LRP; Down's syndrome; ApoE4; electrophysiology; HMG CoA reductase; hippocampus; hippocampal slices; lipids; LDL; LDLR; VLDLR; LRP receptor; LTP; long term potentiation; lipid; Niemann Pick type C (NPC) disease; plasticity; memory
Abstract: Since 1987 we know that "apolipoprotein E-containing lipoproteins may function to redistribute lipid and regulate cholesterol homeostasis within the brain". In 1993 we learned about the importance of "cholesterol synthesis and lipoprotein reuptake during synaptic remodeling". Over the past decade this knowledge was amassed (thanks to the pivotal contribution by many scientists) and elucidated the role for the failure of cholesterol homeostasis proper in neuronal degeneration. Still many questions remain. However, the statement that "a breakdown of cholesterol homeostasis may also play a role in neurodegenerative processes that have not been associated with this lipid so far" seems outdated.
Authors:Alexei R. Koudinov
Authors Institution: Russian Academy Med Sci, Moscow, Russian Federation, c/o P.O.Box 1665, Rehovot 76100 Israel, email: alexei[at]koudinov.info
Key words: cholesterol homeostasis; neurodegeneration; lipoprotein; apolipoprotein; LRP; Down's syndrome; ApoE4; electrophysiology; HMG CoA reductase; hippocampus; hippocampal slices; lipids; LDL; LDLR; VLDLR; LRP receptor; LTP; long term potentiation; lipid; Niemann Pick type C (NPC) disease; plasticity; memory
<< Home