Induction of cholesterol efflux in the CNS
Citation: Rebeck WG. Induction of cholesterol efflux in the CNS. Neurobiol Lipids Vol. 3, 1 (29 Feb 2004). Available at: http://neurobiologyoflipids.org/content/3/1/
Abstract: Intricate cellular mechanisms exist for maintaining proper cholesterol levels. Several recent studies of removal of excess cholesterol in the CNS have focused on the ABC-A1 lipid transporter and its regulation via the LXR nuclear hormone receptor. Cellular cholesterol is hydroxylated to form oxysterols (24-hydroxycholesterol in the brain), which bind LXR and promote gene transcription. LXR activation increases levels of ABC-A1 and apoE, which together act to remove cholesterol and other lipids from cells. Recent studies including Liang et al. suggest manipulation of the LXR system alters brain cholesterol homeostasis and apoE levels, and thus could be beneficial in approaches to Alzheimer disease therapeutics.
Author: G. William Rebeck
Authors Institution: Department of Neuroscience, Georgetown University, 3970 Reservoir Rd, NW, Washington, DC 20057-1464 USA
Key words: apolipoprotein; apoE; ABC-A1; LXR; oxysterols; Alzheimer's disease; cholesterol homeostasis efflux; neurodegeneration; lipoprotein; apolipoprotein; LRP; Down' syndrome; ApoE4; HMGCoA reductase; lipids; LDLr; LRP receptor; injury; Niemann Pick C (NPC)
Abstract: Intricate cellular mechanisms exist for maintaining proper cholesterol levels. Several recent studies of removal of excess cholesterol in the CNS have focused on the ABC-A1 lipid transporter and its regulation via the LXR nuclear hormone receptor. Cellular cholesterol is hydroxylated to form oxysterols (24-hydroxycholesterol in the brain), which bind LXR and promote gene transcription. LXR activation increases levels of ABC-A1 and apoE, which together act to remove cholesterol and other lipids from cells. Recent studies including Liang et al. suggest manipulation of the LXR system alters brain cholesterol homeostasis and apoE levels, and thus could be beneficial in approaches to Alzheimer disease therapeutics.
Author: G. William Rebeck
Authors Institution: Department of Neuroscience, Georgetown University, 3970 Reservoir Rd, NW, Washington, DC 20057-1464 USA
Key words: apolipoprotein; apoE; ABC-A1; LXR; oxysterols; Alzheimer's disease; cholesterol homeostasis efflux; neurodegeneration; lipoprotein; apolipoprotein; LRP; Down' syndrome; ApoE4; HMGCoA reductase; lipids; LDLr; LRP receptor; injury; Niemann Pick C (NPC)
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