The emerging neurobiology of cholesterol
Citation: Simmonds MA. The emerging neurobiology of cholesterol. Neurobiol Lipids Vol. 1, 1 (10 July 2002). Available at: http://neurobiologyoflipids.org/content/1/1/
Abstract: Although cholesterol gets a bad press as a cause of vascular disease, it is, of course, an essential component of all mammalian cells. In neurobiology, three quite different roles of cholesterol can be discerned: as a structural component of the plasma membranes of neurones and glia; as the precursor for a cascade of steroidal hormones and mediators affecting both genomic and non-genomic processes in neurones; and as a direct modulator of the functions of certain plasma membrane proteins.
Author: Mike A Simmonds
Authors Institution: Department of Pharmacology, School of Pharmacy, 29/39 Brunswick Square London WC1N 1AX UK, mikesimmonds@neurobiologyoflipids.org
Key words: Alzheimer; Alzheimer's disease; amyloid beta precursor; cytoskeleton; Down syndrome; etiology; lipids; learning; memory; lipoprotein; receptor; LTP; neurodegeneration marker; oxidative stress; PHF NFT tau phosphorylation; phospholipids; secretase; synaptic plasticity; SREBP; therapy
Abstract: Although cholesterol gets a bad press as a cause of vascular disease, it is, of course, an essential component of all mammalian cells. In neurobiology, three quite different roles of cholesterol can be discerned: as a structural component of the plasma membranes of neurones and glia; as the precursor for a cascade of steroidal hormones and mediators affecting both genomic and non-genomic processes in neurones; and as a direct modulator of the functions of certain plasma membrane proteins.
Author: Mike A Simmonds
Authors Institution: Department of Pharmacology, School of Pharmacy, 29/39 Brunswick Square London WC1N 1AX UK, mikesimmonds@neurobiologyoflipids.org
Key words: Alzheimer; Alzheimer's disease; amyloid beta precursor; cytoskeleton; Down syndrome; etiology; lipids; learning; memory; lipoprotein; receptor; LTP; neurodegeneration marker; oxidative stress; PHF NFT tau phosphorylation; phospholipids; secretase; synaptic plasticity; SREBP; therapy
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