VASSILIOS PAPADOPOULOS, D.Pharm., Ph.D

based in Washington, D.C.

Dr. Papadopoulos research focuses on understanding the cellular and molecular mechanisms responsible for the initiation and maintenance of steroid biosynthesis in the adrenal, gonads and brain, in health and disease. We also examine the regulation of steroid biosynthesis by hormones, chemicals, drugs, natural products and environmental factors with the goal of understanding the pathophysiology of steroidogenesis and developing new tools for the treatment of diseases related to elevated or low steroid levels. In these studies we are using biochemical, pharmacological, and molecular methods to identify the physiological role of critical components of the steroidogenic pathway and identify pathological situations created by changes in the expression of these components in animals and humans. Drug design methods and molecular modeling help us modify existing chemical entities and generate novel ones targeted at key elements of the steroidogenic machinery. Our research has direct applications in reproduction and development, cancer, stress-related disorders, aging and neurodegeneration.

Dr. Papadopoulos articles at PubMed | Dr.Papadopoulos Departmental web page | Dr.Papadopoulos editorial contact