MAKOTO MICHIKAWA, MD, PhD

based in Obu, Japan

Dr. Michikawa is working on the subject comprising the journal scope for many years. His contribution includes elucidation of i) the role of Niemann-Pick disease type C1 protein in cholesterol metabolism and tau phosphorylation in neurons, ii) the interaction of amyloid beta-protein with cellular cholesterol and phospholipid metabolism, iii) the association of amyloid beta-protein biology with high-density-lipoproteins (HDL), and iv) the role of cholesterol in the amyloid cascade, a widely accepted concept for initiation and promotion of the pathology in Alzheimer's disease.

Key words: cholesterol, sphingomyelin, phospholipids, tau phosphorylation, raft, signal transduction, cholesterol release, oligomeric amyloid beta-protein, Alzheimer's disease, oxidative stress, lipid peroxidation, neurodegeneration

Dr. Michikawa articles at PubMed | Dr. Michikawa lab home page | Dr. Michikawa editorial contact